Biological Agents in the Treatment of Rheumatoid Arthritis
نویسندگان
چکیده
منابع مشابه
Treatment of Rheumatoid Arthritis with Biological Agents
Cytokines and Rheumatoid Arthritis The term “cytokine” is coined from the combination of “cyto”, a prefix which means cell, and “kine”, which denotes movement. Cytokines all have the following features: 1. They are low-molecular-weight glycoproteins that are not hormones. 2. They have an effect at very small concentrations. 3. Different cytokines can have the same function (redundancy). For exa...
متن کاملBiological agents in rheumatoid arthritis.
Rheumatoid arthritis (RA) is the commonest inflammatory joint disease with considerable morbidity and mortality. Conventional disease-modifying antirheumatic drugs like methotrexate form the cornerstone of therapy. However, they have several limitations in terms of slow onset of action, adverse effects and modest remission and retention rates. Several cytokines are involved in the pathogenesis ...
متن کاملThe use of biological agents in the treatment of rheumatoid arthritis.
Rheumatoid arthritis is a common and potentially devastating condition which did not have good treatment options until recently. Pharmacological treatment should not just comprise antiinflammatory agents and corticosteroids. The current therapeutic approach is to start a disease modifying agent early in the illness to prevent eventual joint damage. Older disease modifying anti-rheumatic drugs (...
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A wealth of studies has demonstrated that patients with rheumatoid arthritis (RA) are at increased risk of cardiovascu-lar morbidity and mortality, and that this increase is manifest early in the course of RA. 1 2 Another wealth of studies has shown the increasing effi cacy of recent therapies, or therapeutic strategies, in reducing disease activity in RA. As the infl ammatory burden in RA may ...
متن کاملBiologic agents in the treatment of rheumatoid arthritis.
Advances in the understanding of the pathogenesis of rheumatoid arthritis (RA) as well as improved biotechnology has enabled selective targeting of the pathogenic elements of disease. Targeting cell recruitment through adhesion molecules has been shown to be successful in pre-clinical murine models. Results of studies of an anti-ICAM-1 monoclonal antibody and anti-sense oligonucleotides have be...
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ژورنال
عنوان ژورنال: Journal of Bangladesh College of Physicians and Surgeons
سال: 1970
ISSN: 1015-0870
DOI: 10.3329/jbcps.v29i1.7168